伊曲康唑胶囊的人体药代动力学研究  

SERUM PHARMRCOKINETICS OF ITRACONAZOLE AFTER MULTIPLE ORAL DOSES IN 9 HEALTHY CHINESE VOLUNTEERS

作　　者：白林[1] 陈秀兰[1] 吕晓川[1] 王晓蕾[1] 高翠萍[1] 

机构地区：[1]中国人民解放军总医院,北京100853

出　　处：《解放军药学学报》1998年第3期133-136,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：本文采用反相高效液相色谱法,测定9名男性健康志愿者口服伊曲康唑胶囊200mg(100mg×2粒)后的血药浓度,以3p87实用药代动力学程序,计算稳态后一次给药的药代动力学参数。结果消除相(t_(1/2))平均为41.88h;Tmax平均为4.38h;Cmax平均为1230.85ng·ml^(-1);AUC平均为51856.49ng·h·ml^(-1)。The serum pharmacokinetics of itraconazole were investigated in 9 healthy Chinese volun-teers . It raconazole was given at the dose of 200mg, bid for 7 days, oral adminitration of the last dose on the 8th day.The blood samples were collected before dosing and 1,2,4,6,8and12 hours after the first dose(day 1),before dosing on days 2,3,5and 7,and before and 1,2,4,6,8,12,48,96,144 and 168 hours after the last dose. The serum levels of itraconazole were determined by high performance liquuid chromatography. The 3p87 software was used for the calculation of pharmacokinetic parameters. The mean value for maxium concentration of itraconazole in serum was 1 230.85ng·ml-1, mean time to reach peak level in serum was 4.38h,mean serum eliminative half-life was 41.88h,mean AUC was 51 856.49ng·h-1ml-1.

关 键 词：伊曲康唑 药代动力学 血药浓度 

分 类 号：R96[医药卫生—药理学]