产前母血中检出弓形体、巨细胞病毒及Ⅱ型单纯疱疹病毒者围产儿结局的初步探讨  

Perinatal Outcomes in Pregnancies with Toxoplasma, Cytomegalovirus and Herpes Simplex Type Ⅱ Detected in Maternal Blood

作　　者：刘伯宁[1] 匡幼心 刘德莉[1] 张剑麟[1] 戴鍾英 陶雯琪[1] 张慧娟[1] 

机构地区：[1]上海市第六人民医院妇产病理研究室,200233

出　　处：《中华围产医学杂志》1998年第3期138-141,共4页Chinese Journal of Perinatal Medicine

摘　　要：目的从围产儿结局探讨产前弓形体、巨细胞病毒及单纯疱疹病毒Ⅱ型 DNA 多聚酶链反应(PCR)检测的必要性。方法采用 PCR 技术对母血、胎盘组织及(或)脐血进行弓形体、巨细胞病毒及单纯疱疹病毒Ⅱ型病原体检测。结果 1 141例孕妇产前弓形体、巨细胞病毒及单纯疱疹病毒Ⅱ型检测中,97例检出病原体,检出率8.50%,弓形体、巨细胞病毒及单纯疱疹病毒Ⅱ型的检出率分别为4.82%,2.72%及2.28%。围产儿结局不同的两组,其胎盘组织及(或)脐血中病原体的检出率分别为17.65%及60.00%(P<0.05)。结论孕妇产前弓形体、巨细胞病毒及单纯疱疹病毒Ⅱ型检测很有必要,母血阳性者应将胎盘及其附属物送检;对母血阳性的围产儿,应密切随访。Objective To study the perinatal outcomes in pregnant women with pathogens of toxoplasma,cytomegalovirus and herpes simplex type Ⅱ in maternal blood.Methods 1 141 preg- nant women were screened for toxoplasma,eytomegalovirus and herpes simplex type Ⅱ by PCR in maternal blood during 1994.2～1997.3.Some placental tissues and/or umbilical vein blood were also detected.Results Toxoplasma,cytomegalovirus,or herpes simplex type Ⅱ were positive in 97 cases(8.50%).All cases,except that 25 cases did not deliver in our hospital,were followed up to 42 days postpartum.Fifty-two cases got good perinatal outcomes,while 20 cases had poor perinatal outcomes.17 placentas were detected in patients with good perinatal outcomes,while 15 placentas were detected in patients with poor perinatal outcomes.The positive rates of toxoplasma,cytomega- lorirus and herpes simpley type Ⅱ in the two groups were 17.65%(3/17)and 60.00%(9/15)re- spectively(P<0.05).Conclusions Routine screening of toxoplasma,cytomegalovirus and herpes simplex type Ⅱ for pregnant women was important,especially for mothers with history of poor peri- natal outcomes.Mother's blood with positive toxoplasma,cytomegalovirus,or herpes simplex type must be followed up closely and treated if possible,and their placental pathogens should also be detected.

关 键 词：胎儿 感染 聚合酶链反应 弓形虫属 巨细胞病毒 人 疱疹病毒2型 人 

分 类 号：R714.7[医药卫生—妇产科学]