胎膜早破孕妇血清及羊水中细胞因子的变化  

The Changes of Cytokine in the Amniotic Fluid and Maternal Serum in Patients with Premature Rup- ture of Membranes

作　　者：张为远[1] 王丽[2] 张艳丽[2] 叶青[2] 

机构地区：[1]白求恩医科大学第二临床学院妇产科,长春130041 [2]解放军第208医院妇产科

出　　处：《中华围产医学杂志》1998年第1期13-15,共3页Chinese Journal of Perinatal Medicine

摘　　要：目的探讨细胞因子联合监测在胎膜早破中的作用。方法采用放射免疫法和酶联免疫吸附实验对46例胎膜早破孕妇母血清、羊水中白细胞介素(IL)6、IL-8和肿瘤坏死因子-α水平进行监测,并以正常足月妊娠孕妇26例做对照组。结果胎膜早破孕妇母血清中 IL-6、IL-8和羊水中IL-6、IL-8,肿瘤坏死因子-α水平均较正常足月妊娠组高,差异显著(P<0.01;P<0.05);母血清中肿瘤坏死因子-α虽高于对照组,但差异不显著(P>0.05);随着破膜时间延长母血中 IL-6、IL-8和羊水中 IL-6、IL-8及肿瘤坏死因子-α有增加趋势;绒毛膜羊膜炎患者13例,其母血、羊水中上述三种细胞因子水平均明显高于非绒毛膜羊膜炎患者,差异显著(P<0.05)。结论细胞因子联合监测对识别胎膜早破孕妇存在绒毛膜羊膜炎起辅助诊断作用。Obstective To study the role of determining some cytokines in patients with pre- mature rupture of membranes (PROM).Methods The 26 normal term pregnant women as con- trol,46 patients with premature rupture of membrane were enrolled for study.Maternal serum and amniotic fluid IL-6,IL-8 and TNF-α levels were detected by a sensitive radioimmunoassy and an en- zyme labded immnosorbentassay.Results The maternal serum IL-6,IL-8 levels and amniotic fluid IL-6,IL-8 and TNF-α levels in PROM group were higher than those of control,there were significant difference (P<0.05-P<0.01),Although the levels of TNF-α in maternal serum were higher than those of control (P<0.05).There were significant relationship between maternal IL-6,IL-8,TNF-α and duration of the pemature rupture of membranes,the longer was time the higher were the mater- nal IL-6,IL-8 and TNF-α;there were 13 cases patients complicated with chorioamnionitis,and their maternal serum and amniotic fluid IL-6,IL-8 and TNF-α were higher than those of nonchorioam- niotinis(P<0.05).Conclusion Determining cytokine is valuble clinical index for identificating the chorioamnionitis in patients with premature rupture of membranes.

关 键 词：胎膜早破 白细胞介素6 肿瘤坏死因子 绒毛膜羊膜炎 

分 类 号：R714.433[医药卫生—妇产科学]