胃癌及癌旁组织癌胚抗原分布的免疫电镜观察  

IMMUNOELECTRON MICROSCOPIC OBSERVATION OF CARCINOEMBRYONIC ANTIGEN DISTRIBUTION IN GASTRIC CANCER AND ADJACENT TISSUE

作　　者：吴继锋[1] 杨光霖[1] 董聿明 

机构地区：[1]安徽医科大学病理解剖学教研室

出　　处：《中国组织化学与细胞化学杂志》1998年第1期84-87,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金

摘　　要：应用免疫电镜技术对１４例胃癌手术切除标本进行胃癌及癌旁组织中癌胚抗原（ＣＥＡ）超微结构水平分布的定位观察。结果表明，癌旁正常胃粘膜上皮细胞ＣＥＡ含量很少，仅在表面微绒毛见到微弱的ＣＥＡ分布；肠化上皮细胞ＣＥＡ主要分布在吸收细胞的微绒毛及杯状细胞粘液颗粒之间；而胃癌细胞ＣＥＡ除分布腔面微绒毛外，尚分布细胞侧面，基底面或整个胞膜，还见于胞浆内膜结构中。ＣＥＡ在胃癌细胞与正常胃粘膜上皮及肠化上皮分布上的差异说明表面膜成份极性的丧失是上皮性肿瘤细胞的特征之一。ＣＥＡ在胃癌细胞的分布异常可能导致恶性细胞某些生物学行为的变化。The ultrastructural distribution of CEA in gastric cancer and adjacent tissue from 14 patients was observed by immunoelectron microscopic technique. The results showed that there was little or no CEA on the microvilli of normal gastric mucosa. In intestinal metaplasia CEA was found among the microvilli of absorptive cells and the mucus particles of goblet cells. But in gastric cancer, CEA was distributed on the lateral and basal surfaces or even over the entire surface of the cancer cells, besides on the apical microvilli surface. CEA was also found in intracellular membrane structure. The deviations of the distribution of CEA in gastric cancer cells from normal epithelium and intestinal metaplasia suggest that loss of polatrity of surface membrane is one of the characteristcs of neoplastic epithelial cells. The abnomal distribution of CEA might lead to important changes in the biological behavior of the cancer cells.

关 键 词：胃肿瘤 肠上皮化生 癌胚抗原 免疫电镜 

分 类 号：R735.2[医药卫生—肿瘤] R466.6[医药卫生—临床医学]