细支气管肺泡细胞增生和细支气管肺泡细胞癌内生长因子和蛋白激酶C的表达  

EXPRESSION OF GROWTH FACTORS AND PROTEIN KINASE C IN BRONCHIOLO ALVEOLAR CELL HYPERPLASIA AND BRONCHIOLO ALVEOLAR CARCINOMA

作　　者：曾庆富[1] 颜亚晖[1] 蒋海鹰[1] 钱仲斐[1] 

机构地区：[1]湖南医科大学病理学教研室

出　　处：《中国组织化学与细胞化学杂志》1998年第1期88-91,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金

摘　　要：表皮生长因子（ＥＧＦ）、转化生长因子－α（ＴＧＦα）、表皮生长因子受体（ＥＧＦＲ）和蛋白激酶Ｃ（ＰＫＣ）与细胞生长、增殖分化调节和细胞癌变有密切关系。作者用免疫组织化学方法检测了细支气管肺泡细胞增生（ＢＡＨ）和细支气管肺泡细胞癌（ＢＡＣ）的ＥＧＦ、ＴＧＦα、ＥＧＦＲ和ＰＫＣ表达。结果表明：ＢＡＣ中的ＥＧＦ、ＴＧＦα阳性率和阳性强度以及ＥＧＦＲ、ＰＫＣ阳性强度均明显高于ＢＡＨ。ＢＡＨ的重度不典型增生病例，其ＥＧＦ、ＴＧＦα、ＥＧＦＲ和ＰＫＣ均呈高表达。ＴＧＦα、ＥＧＦＲ和ＰＫＣ三者在ＢＡＣ和ＢＡＨ中的表达存在明显相关性。提示：ＴＧＦα及其受体ＥＧＦＲ和ＰＫＣ是细支气管肺泡细胞增生、恶性转化和肺泡癌细胞失控生长的重要因素。Epidermal growth factor(EGF). its related peptide transforming growth factor (TGFα) and their common receptor(EGFR) and protein kinase C(PKC) have been implicated in the control of cell proliferation, differentiation and may play an important role in cell carciogenesis. We have compared the immunohistochemical expression of these peptides in brochiolo alveolar cell hyperplasia(BAH) and brochiolo alveolar carcinoma(BAC) and observed: (1)increased positive rates of EGF TGFα and extended staining intensity of all these peptides in BAC obviously higher than those in BAH; (2)with severe dysplasia all those peptides of BAH are in high expression; (3) there is close relationship among TGFα, EGFR and PKC in BAC or BAH. The results that altered expression of TGFα and its receptor EGFR and PKC must be the improtant causes for the proliferation, carcinogensis of bronchiolo alveolar epithelium and for the uncontroled growth of BAC.

关 键 词：表皮生长因子 表皮生长因子受体 蛋白激酶C 肺癌 免疫组织化学 

分 类 号：R392.11[医药卫生—免疫学]