感染日本血吸虫小鼠心房特殊颗粒的形态学观察和定量分析  

MORPHOLOGIC AND QUANTITATIVE STUDY OF ATRIAL SPECIFIC GRANULES IN MICE INFECTED WITH SCHISTOSOMA JAPONICUM

作　　者：赵雪云[1] 陈静卿[1] 姚万红[1] 

机构地区：[1]湖北医科大学寄生虫学教研室

出　　处：《中国组织化学与细胞化学杂志》1998年第1期92-95,共4页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：小鼠感染日本血吸虫尾蚴后第２８天，右心耳心房特殊颗粒数目显著减少，且多见膜溶解、断裂，半月形排空和颗粒膜与横管膜及肌膜靠近、融合及颗粒向横管腔及肌膜下突出的现象。心肌细胞内线粒体有肿胀、基质变浅及部分嵴断裂现象。感染组小鼠右心耳心房特殊颗粒的体密度（０．０３２３±０．００２９μｍ３／μｍ３）、面数密度（０．８６４７±０．０６９２μｍ－２）、数密度（３．２３６３±０．１１１４μｍ－３）及颗粒平均直径（０．２６７１±０．０２０７μｍ）均显著小于对照组的０．０９７１±０．０１２７μｍ３／μｍ３、１．９２１±０．１１４５μｍ－２、０．２１８９±０．０８６６μｍ－３和０．３１０８±０．０１９５μｍ。本文阐述了日本血吸虫感染后，促进心房特殊颗粒释放增加。28 days following infection of cercaria of Schistosoma japonicum, the number of atrial specific granules (ASG) in the right auricle of mice was decreased significantly and in some of the granules, the phenomenon of dissolving and breaking of membrane, half moon like excluding, closing and merging of ASG and the membrane of the transverse tube and sarcolemma in the heart muscle cells and protruding of ASG towards the lumen of the transverse tube and sarcolemma were often observed. Many mitochondria in the heart muscle cells showed swelling, shallowing of matrix and breaking of parts of the cristae. The ASG volume density (0 0323±0 029μm 3/μm 3), numerical density on area (0 8647±0 0692μm -2 ), numerical density (3 2363±0 1114μm -3 and mean diameter (0 2671±0 0207μm) in the tested group were respectively less than those (0 0971±0 0127μm 3/μm 3,1 921±0 1145μm -2 ,6 2189±0 0866μm -3 ,0 3108±0 0195μm) in the control group. The relationship between ASG and the Schistosoma japonicum infection was briefly discussed.

关 键 词：日本血吸虫 心房特殊颗粒 免疫组织化学 

分 类 号：R392.11[医药卫生—免疫学] R383.24[医药卫生—基础医学]