削痂对深Ⅱ度烧伤局部生长因子释放及愈合的影响  

The Effect of Tangential Excision on the Release of Local Growth Factors and Wound Healing in the Deep-Partial Thickness Burn

作　　者：陆树良[1] 金曙雯[1] 青春[1] 史济湘[1] 丁长囡 

机构地区：[1]上海第二医科大学附属瑞金医院,上海市烧伤研究所200025

出　　处：《上海交通大学学报（医学版）》1997年第S1期23-26,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金!39290700-5

摘　　要：为探讨削痂手术对深Ⅱ度烧伤创面局部生长因子水平及创面愈合的影响，对7例烧伤患者深Ⅱ度创面中削痂手术前、手术后和未手术之创面组织在体外组织培养中释放EGF、bFGF、PDGF－AB水平进行检测和病理学观察。研究发现，削痂手术后创面组织释放EGF、bFGF、PDGF－AB水平较手术前和未手术创面有显著升高；局部组织病理学观察显示，手术后创面新鲜肉芽形成和表皮修复程度较手术前和未手术创面显著。实验提示，削痂手术可以增加创面局部组织释放EGF、bFGF、PDGF－AB，对深Ⅱ度烧伤创面愈合有促进作用。In this article, the effect of tangential excision on the release of local growth factors and wound healing in the deep-partial thickness burn were under study. From 7 patients with deep-partial thickness burn, the tissue specimens were cultured in vitro, respectively from pre-operation,post-operation and non-operation wounds. We assayed the levels of EGF, bFGF and PDGF- AB in the culture medium and did pathological examination of the tissue samples to observe the status of wound healing. The results showed that levels of EGF, bFGF and PDGF-AB were much higher in the post-operation wounds than in the pre-and non- operation wounds. The pathological examination also reveraled that the fomation of fresh granulation and epidermis repairs were more evident in the post-operation wounds than in the pre-and non-operation wounds. The results suggest that the tangential excision could increase the local production of EGF, bFGF and PDGF-AB and improve the wound healing in the deep-partial thickness burn.

关 键 词：烧伤 削痂 生长因子 创面愈合 

分 类 号：R644[医药卫生—外科学]