大肠慢性血吸虫病细胞DNA含量及花生凝集素受体的研究  

Study on the Cellular DNA Content and the Peanut Lectin Receptor of Chronic Schistosomiasis of Large Bowel

作　　者：刘南植[1] 余金生[1] 尹朝礼[1] 

机构地区：[1]同济医科大学附属同济医院内科,武汉430030

出　　处：《华中科技大学学报（医学版）》1997年第S1期31-33,36,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：应用流式细胞术和LSAB亲合细胞化学染色法观察大肠慢性血吸虫病细胞DNA含量及花生凝集素(PNA)受体的变化,以探讨血吸虫病与大肠癌的关系。结果表明,42例大肠慢性血吸虫病(包括18例血吸虫卵息肉)细胞DNA含量及PNA受体均无明显异常,而12例血吸虫病合并大肠癌和11例单纯大肠癌及其癌周粘膜在以上两方面亦均未显示出明显差异。本组资料未能证实慢性血吸虫病肠道病变具有癌前病变的性质,血吸虫病与大肠癌可能为伴存关系。In order to define the relationship between schistosomiasis and colorectal carcinoma, the cel- lular DNA content and the peanut agglutinin receptor of chronic schistosomiasis of large bowel were surveyed by flow cytometry and by immunohistochemically LSAB method. The results indicated that there was no ob- vious abnormality in the cellular DNA content and the peanut lectin receptor of 42 cases of chronic schistoso- miasis of large bowel, including 18 in company with ova polyps, and no apparent difference in the two above- mentioned aspects between 12 colorectal carcinomas associated with schistosomiasis and 11 simple colorectal carcinomas, and between their mucosas surrounding the cancers. Our data do not verify that chronic schisto- somiasis of large bowel is the characteristic of premalignant lesions, there is no direct correlationship between schistosomiasis and colorectal carcinoma, which is mainly co-existent.

关 键 词：血吸虫病 DNA含量 凝集素 

分 类 号：R532.21[医药卫生—内科学]