T_(1-2)的抗再灌注心律失常及抗心肌梗塞作用  

Protective Effect of T1-2 on Reperfusion-Induced Arrhythmia and Experimental Myocardial Infarction in Rats

作　　者：蒋建敏[1,2,3] 陈保青 戴德哉[1,2,3] 

机构地区：[1]中山大学药学系药理研究室 [2]深圳健安医药公司 [3]中国药科大学药理研究室

出　　处：《中山大学学报（自然科学版）》1997年第S2期46-50,共5页Acta Scientiarum Naturalium Universitatis Sunyatseni

摘　　要：研究Ｂｅｐｒｉｄｉｌ（Ｂｅｐ）的衍生物Ｔ１－２的抗心律失常及抗心肌梗塞作用．麻醉大鼠冠脉结扎再灌注诱发心律失常，记录心律失常分数，再行结扎３ｈ，取心肌ＴＴＣ染色测梗塞区．Ｔ１－２２．５，５ｍｇ／ｋｇ（ｉｐ）降低再灌注ＶＴ的发生率，分别降低了３６％（Ｐ＞０．０５），６２％（Ｐ＜０．０５），降低梗塞区范围，分别降低了２６％和４１％．所以Ｔ１－２具有与Ｂｅｐ相仿的抗心律失常及抗心肌缺血活性．To study the effects of antiarrhythmia and antimyocardial infarction by T1-2, a Bepridil (Bep) analogous. Experimental arrhythmia and infarction induced by ischemiareperfusing and ligating (3 h) the rat left coranary artery, the arrhythmic scores were estimated, myocardial infarction zone (IZ)was determined by TTC technique. The incidence of reperfusion induced ventricular tachycardia (VT) was obviously reduced by T1-2 25, 50 mg/kg (ip). The inhibitory rate was 36% (P>005) and 62% (P<005), respectively. Furthermore, T1-2 played a remarkable role in diminishing the IZ and the inhibitory rate was 26% and 41%, respectively. So T1-2 possesses the same protective effects of Bep on ischemic myocardium and suppressive effect on arrhythmias.

关 键 词：T_1-2 缺血—再灌 心律失常 心肌梗塞 BEPRIDIL 

分 类 号：R972.2[医药卫生—药品]