人参固本口服液的药理实验研究  

EXPERIMENTAL STUDY OF PHARMACOLOGY OF RENSHEN GUBEN ORAL LIQUID

作　　者：周恩平[1] 李运伦[1] 杨勇[1] 王苓[1] 姚晓渝[1] 

机构地区：[1]山东中医药大学,济南250014

出　　处：《生物医学工程研究》1997年第4期45-48,共4页Journal Of Biomedical Engineering Research

摘　　要：人参固本口服液系人参固本丸改变剂型 ,具有吸收快 ,便于服用之优点。为验证其药理药效 ,对新老两种剂型进行了主要药效学对比实验 ,结果显示 :人参固本丸及口服液对小鼠均有明显的抗疲劳、耐缺氧作用 ,可提高小鼠腹腔内巨噬细胞的吞噬功能 ;对阴虚模型动物滋阴补肾及抗氧化作用实验表明 :二者对阴虚小鼠的甲状腺、胸腺、肾上腺均有增加趋势 ,尤其胸腺明显增大 ,说明二者均有滋阴补肾 ,改善因肾虚所致内分泌腺体萎缩 ,使失调的功能恢复至生理平衡状态 ,提高机体免疫功能的作用 ,并可使小鼠血液及胸腺组织中SOD活力显著提高 ,使血浆及脑组织中MDA含量明显下降 。Renshen Guben Bolus and its preparation of Roal Liquid both have remarkable anti-fatigue and anoxia-resistant effect and enhance the macrophaging function of the macrocytes in the absominal cavity of the mice. The experiment on tonifying the kidney yin and counteracting oxidation in animal model of yin deficiency shows that the thoracic gland of the enlarged obviously, indicating that both the bolus and oral liquid have the function of nourishing yin, tonifying the kidney, restouing the disturbed funtion to a physiological state, enhancing the immunity of the body and activating the activity of the SOD in the blood and thoracic glands of the mice, decreasing the MDA contents of plasma and cerebral tissues notably. This shows that both the bolus and oral liquid have strong free-radical-eliminating and antilipid-hyperoxidation effects.

关 键 词：人参固本口服液 肾阴虚 超氧化物歧化酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]