血液透析患者HCV感染的基因分型及其危险因素  

The status and genotypes 0f hepatitis C virus infection and its risk factors of haemodialysis patients

作　　者：苏虹[1] 吴系科[1] 倪进发[1] 毕鹏[1] 

机构地区：[1]安徽医科大学流行病学教研室,合肥230032

出　　处：《中华疾病控制杂志》1997年第3期180-182,共3页Chinese Journal of Disease Control & Prevention

摘　　要：为了解血透患者HCV感染水平及其危险因素，我们调查了安徽省七所医院中104例血透患者。主要检测指标：抗-HCV选用EIA法，HCVRNA选用逆转录-聚合酶链反应（RT－PCR）法，HCV基因分型选用限制性片段长度多态性分析（RFLP）法。结果表明本组血透患者抗-HCV阳性率为5769％，HCVRNA阳性率为24．04％，HCV基因型有Ⅱ、Ⅲ、Ⅱ、／Ⅲ混合型，检出率分别为32％、20％、36％。提示血透患者HCV感染以Ⅱ／Ⅲ混合型为主。血透患者感染HCV与透析次数多少及输血次数多少有关，血液透析的危险性高于输血，两者有交互作用。In order to analyze the prevalence of anti-HCV and its infection factors of the haemodia1ysis patients, l04 haemodialysis cases were studied and their sera collected. The prevalence of anti-HCV was 57. 69% and that of HCVRNA was 24. O4%. HCV ⅡⅢ and Ⅱ /Ⅲ genotypes could be observed in haemodialysis patients and the mix type accounted for 36%. The infection rate of HCV had no significant difference in treatment and blood transfusion history played an important role in the high risk of HCV infection in haemodialysis patients. The more in number and the longer in time of haemodialysis, the more danger in infection. The haemodialysis was more dangerous than blood transfusion and there was effect modification between them. So it was essential to monitor and improve haemodialysis, and to screen the blood donors.

关 键 词：血液透析 丙型肝炎 危险因素 

分 类 号：R459.5[医药卫生—治疗学]