安徽某供血员人群HCV感染慢性化趋势的流行病学研究  

An epidemiological study on chronic tendency for HCV infection of blood donors in one area in Anhui

作　　者：阚晓宏 倪进发[1] 毕鹏[1] 孙业桓[1] 程慧[1] 郑惠玲[1] 黄守凯[2] 张庶民[3] 

机构地区：[1]安徽医科大学流行病学教研室,合肥230032 [2]安徽医科大学儿少卫生教研室 [3]中国药品生物制品检定所

出　　处：《中华疾病控制杂志》1997年第2期107-109,共3页Chinese Journal of Disease Control & Prevention

基　　金：安徽省自然科学基金

摘　　要：选择安徽某“职业”供血员中，1992～1996年间抗-HCV（＋）和／或HCVRNA（＋）共118例调查对象。追访了他们HCV感染及其后演变的有关重要临床诊治和流行病学信息，同时调查HCV感染者的现况和实验检测指标，描述了供血员人群HCV感染后慢性化率变化趋势。结果HCV感染6mon后慢性化率为55．93％，1年至4年慢性化率依次为50％，48.54％，46．47％和46．43％。表明HCV感染后慢性化率一直持续高水平，下降缓慢，尤其2年后基本稳定在46％～48％之间，远高于乙型肝炎5％～10％的慢性化率。In order to explore the chronic tendency of HCV infection, a descriptive epidermiological study was conducted. Serum samples and clinical epidemiological data, such as initial infection date, detection data of liver function for different disease courses, were collected from 118 HCV infection cases of 'professional' blood doors (anti-HCV (+) or/and HCV RNA (+ ) )in one area in Anhui from l992 to l996.The results showed that six months later, chronic rate was 55. 93% after HCV infection,one year for 5O%, two years for 48. 54 %, three years for 46. 47 %, and four years for 46. 43 % Chronic rate after HCV infection was continuously in high level, decreased slowly, and two years later basically stayed at 46%～48%, greatly higher than hepatitis B with a chronic rate at 5%～10%.

关 键 词：丙型肝炎 慢性化率 流行病学 

分 类 号：R181.3[医药卫生—流行病学]