孕妇沙眼衣原体感染前瞻性研究  

Prospective study on the chlamydia trachomatis infection of pregnant women

作　　者：张桂宁[1] 王全意[2] 张玮[3] 刘海英[1] 戴旻笙[1] 王宇露[3] 

机构地区：[1]山东医科大学流行病学教研室,济南250012 [2]中国医学科学院基础医学研究所 [3]山东省卫生防疫站

出　　处：《中华疾病控制杂志》1997年第1期12-14,共3页Chinese Journal of Disease Control & Prevention

摘　　要：用间接血凝试验检测了273名孕妇血清沙眼衣原体（Ct）抗体，以抗体阳性孕妇为暴露组，抗体阴性孕妇为非暴露组，追踪观察至分娩。暴露组胎膜早破发生率（34．15％）显著高于非暴露组（12．0％）。其他妊娠不良结局两组无显著性差别。对经感染母亲阴道分娩的29名新生儿随访4周，经直接荧光试验证实4例新生儿发生Ct结膜炎或Ct中耳炎。27例感染孕妇分娩后采集了丰水、脐血和胎盘标本，用多聚酶链反应技术检测结果2例阳性，证实Ct可经胎盘引起官内感染。Among the 273 pregnant women in whom IHA for Chlamydia trachomatis were performed, 43 were positive for chlamydia as exposure group, 230 negative as unexposure group.They were followed up into the parturition. The incidence rate of premature rupture of membranes of exposure group (34. 15%) is significantly higher than that of unexposure group (12.0%).There are no statistically significant differences between Chlamydia trachomatis infection and other adverse pregnancy outcome. Chlamydial infection of conjunctivae or otitis media was detected in 4 of these 29 infants (13. 79%) of the group born vaginally to infected mothers and followed up for 4 weeks. In 2 of 4 infected infants, Chlamydial antigen was detected from both conjunctivae and otic secretion. We have first proved 3 cases of otitis media in infants by DFA. 27 sampls of amnionic fluid, cord blood and placental tissues were detected from Ct by using PCR and 2 were positive for Chlamydia. It is proved that vertical transmission of Ct may well be in intrauterine infection.

关 键 词：沙眼衣原体 前瞻性研究 新生儿中耳炎 垂直传播 

分 类 号：R714.25[医药卫生—妇产科学]