TNF_α在人类系膜增生性肾小球肾炎中的作用  

Effect of TNF_αon human esangioproliferative glomerulonephritis

作　　者：任力[1] 刘梦海[1] 李佰祥[1] 臧玉华[2] 石炳华[3] 

机构地区：[1]空军医学高等专科学校,吉林市132013 [2]大连医科大学附属二院,大连市116023 [3]白城市中心医院,白城市137000

出　　处：《空军医高专学报》1997年第1期1-4,共4页

摘　　要：将临床确诊为系膜增生性肾小球肾炎（MsPGN）的118例分为轻、中、重3组,每组随机抽取8例作为实验组;另取3例正常肾组织作为对照组,进行免疫电镜检查。结果显示:正常及空白对照组肾小球内未见金颗粒,轻度MsPGN的系膜细胞（MC）内Go、RER附近有少量散在分布的金颗粒;中度MsPGN增生的MC内金颗粒数增多,Go、RER及Ly附近,与轻度比较有显著性差异（P<0.001）;重度MsPGN增生的MC内见有大量金颗粒聚集呈团、线状或散在分布,与轻、中度MsPGN比较均有显著性差异（P<0.001）。结果表明:TNF_α可由MC产生,随着病变进展TNF_α在MC内逐渐增多。In this study ,118 patients clinically diagnosed as MsPGN were divided into three groups; mild,intermediate and advanced.Eight patients were taken in random from each group and three cases of nomal kidney tissue were selected as control. All -the 27 speciments underwent immunoelectronmicroscopy. The result showed that no gold particles presented in the normal and blank control groups, but a few gold particles were diffused in MC with mild MsPGN tin the intermediate MsPGN gold particles were increased considerably (P<0. 001). In proliferation MC with advanced MsPGN,the gold particles were much more than in mild and intermediate MsPGN groups (P<0. 001). The gold particles were collected in shape of group, liner or diffusion. TNF. was produced by MC and increased gradually with the disease progress.

关 键 词：MSPGN TNF_α MC 免疫电子显微镜术 

分 类 号：R692.3[医药卫生—泌尿科学]