苦参素治疗慢性乙型病毒性肝炎39例临床观察  

Clinical Efficacy of Kurarinone on Chronic Viral Hepatitis Type B: A Report of 39 Cases

作　　者：郭伟[1] 孙海涛[1] 

机构地区：[1]安徽省宿州市中医院肝胆科,234000

出　　处：《实用全科医学》2004年第4期324-325,共2页Applied Journal Of General Practice

摘　　要：目的　观察苦参素治疗慢性乙型病毒性肝炎的临床疗效。方法　对 3 9例慢性乙型病毒性肝炎予以苦参素胶囊 0 .2g口服 ,3次 /日 ,3个月 ;或者予以苦参素注射液 10 0ml静滴 ,1次 /日 ,15天 ,后改苦参素胶囊 0 .2g口服 ,3次 /日 ,75天。观察治疗前后肝功能 ,HBV -M ,HBV -DNA ,及WBC变化。结果　肝功能复常率为 64 .9% ,HBeAg阴转率为 3 8.5 % ,HBV -DNA阴转率为 3 0 .8% ,WBC >4.0× 10 9由治疗前为 7例治疗后为 3 0例。结论　苦参素治疗慢性乙型病毒性肝炎可明显改善肝功能 ,抑制乙肝病毒复制 ,并提高机体免役状态 ,提高血清白细胞数量。Objective To observe the efficacy of kurarinone on chronic Hepatitis B. Methods 39 patients were given kurarinone capsules for 3 months, or after given kurarinone injection for 15 days, kurarinone capsules were given for 75 days. Liver function, HBV-M, HBV-DNA and WBC were detected. Results 64.9% of the patients' liver function converted normal. Turning negative rate of liver function was 64.9%, 38.5% of patients' HBeAg and 30.8% of patients' HBV-DNA converted to negative. After treatment, the total number of patients whose Sum of WBC were above 4.0×10 9 /L rose to 30 from 7 before treatment. Conclusions Kurarinone has certain curative effect on patients with chronic viral hepatitis type B, it can ameliorate the liver function, inhibit the replication of HBV and raise the sum of WBC.

关 键 词：苦参素 慢性乙型病毒性肝炎 病毒复制 HBV 肝功能 

分 类 号：R512.62[医药卫生—内科学]