国产克林霉素磷酸酯注射液体内抗菌作用研究  

Study of Antibacterial Activities of Domestic Clindamycin Injection in Vivo

作　　者：徐济良[1] 凌祥[1] 

机构地区：[1]南通医学院,南通226001

出　　处：《药学与临床研究》1997年第1期1-3,共3页Pharmaceutical and Clinical Research

摘　　要：对国产克林霉素磷酸酯注射液进行体内抗菌试验,并与林可霉素注射液比较。结果显示:静脉注射克林霉素对需氧菌金黄色葡萄球菌、肺炎链球菌和厌氧菌产气荚膜杆菌感染小鼠的保护作用明显强于林可霉素注射液,其中对金葡菌感染小鼠的保护作用比林可霉素强2.3倍,对肺炎链球菌感染小鼠的保护作用比林可霉素强4.4倍,对产气荚膜杆菌的抗菌活性强3.8倍。研究结果表明:国产克林霉素注射液有良好的体内抗菌作用。The antibacterial activities of domestic clindamycin phosphate injection in vivo were studied and compared with those of lincomvcin injection. The results showed that clindamycin injection was more potent than lincomvcin injection when administered intravenously in mouse protection tests against Staphylococcus aureus. Streptococcus pneumoniae and Clostridium perfringens. Clindamycin injection was 2. 3 times, 4. 4 times and 3. 8 times more powerful than lincomvcin against S. aureus,S. pneumoniae and C. perfringens respectively. The results indicated that home made clindamycin injection was a very effective antibacterial agent.

关 键 词：克林霉素注射液 体内抗菌作用 小鼠保护试验 半数保护剂量 

分 类 号：R96[医药卫生—药理学]