小剂量(5mg)舒降之(Simvastatin)对老年人调脂作用的临床研究  

Clinical study of effectiveness with low-dosage(5mg) simvastatin on aged hyperlipidemic patents

作　　者：康丽萍[1] 徐成斌[1] 田雅文[1] 

机构地区：[1]北京医科大学人民医院

出　　处：《岭南心血管病杂志》1996年第4期29-31,63,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的观察小剂量舒降之对高血脂老年人的血脂作用，尤其是对氧化低密度脂蛋白的作用。方法本实验采用自身对照法，观察了３０例高血脂老年人口服舒降之５ｍｇ／日×４周治疗前后的血脂变化，用配对ｔ检验检测其差异显著性。结果小剂量舒降之不仅明显降低ＴＣ（从６．８４±０．９７到５．３２±０．８６ｍｍｏｌ／Ｌ）、ＴＧ（从２．８３±１．９５到２．２２±１．３３ｍｍｏｌ／Ｌ）、ＬＤＬ（从１４４．５６±６０．６６到１０７．７０±２８．５１ｍｇ／ｄｌ）、ＡｐｏＢ（从１２７．４１±６５．１１到８８．８５±４０．６４ｍｇ／ｄｌ），而且ＯＸＬＤＬ明显下降（认５０．３７±２５．４１到３４．０１±１７．７６ｕｇ／ｄｌ），下降率分别为２２％、２１％、２５．５％、３０．３％和３２．５％，均有统计学意义。冶疗高血脂症总有效率为９３．３％，未发现严重副作用。结论小剂量舒降之对老年人降低血胆固醇、抑制ＬＤＬ氧化、调整其他血脂紊乱安全而有效，可考虑长期服用。Objective The paper was designed to study the effectsof low-dosage(5mg) simvastatin on the blood lipids of theaged hyperlipidemic patients, especially on their plasmaOXLDL(oxidized LDL) .Methods In the trial, we used self- control method to oberve the changes of the plasma lipidsin 30 aged hyperlipidemic patients after 4-weeks treatmentwith 5mg/day.The day. The was analysed the differ ences of plasma lipids between Pre-and pest-treatmentwith paired t- test.Results Not only TC(from 6. 84± 0. 97to 5. 32± 0. 86mmoL/L), TG (from2. 83 ± 1. 95 to2. 22 ±1. 33mlnoL/L), IDL(from144. 56±60. 66 to 170. 70 ± 28.sings), ApoB (for 127. 4 ± 65. 11 to 88. 85 ± 40.64mg/dl) reduced, but also OXLDL could reduced(from50.37± 25. 41 to 34. 01±17. 76ug/dl) by low- dosagesimvastatin significantly. The lowering rate was seperately22%, 21%, 25.5%, 30.3%, and 32.5% .Each of themwas statistically significant. The total effeciacy rate in treating hyperlipidemia is 93. 3 %. No significant adverse effectswere occurred. Conelusion Low-dosage simvastatin therapyon reducing plasma cholesterol, inhibiting oxidation of LDLand adjusting the other disorders of lipidemia is safe and effective for aged huperlipidemic patients in 4-weeks treat ment. It may be considered as a long-term therapy method.

关 键 词：舒降之 氧化低密度脂蛋白 动脉粥样硬化 

分 类 号：R969[医药卫生—药理学]