经静脉途径注射自制声振白蛋白左心声学造影的实验研究  

Intravenous contrast echocardiography by using sonicated albumin in dogs

作　　者：查道刚[1] 刘伊丽[1] 秦建新[1] 宾建平[1] 梁文华[1] 谢晋国[1] 贾满盈[1] 

机构地区：[1]第一军医大学附属南方医院心内科

出　　处：《岭南心血管病杂志》1996年第1期37-39,58,共4页South China Journal of Cardiovascular Diseases

摘　　要：观察了经犬股静脉注入自制声振白蛋白左心显影效果．结果：本研究造影剂微泡直径４．２±２．４μｍ，浓度１６５±０６９×１０８／ｍｌ．经股静脉注射该造影剂共１０次，均见右室显影．５～８个心动周期后，左左室相继显影（显影率１００％）．持续约１１～３０个心动周期后左室造影作用消失．结论：声振５％人体白蛋白微泡直径小于红细胞，经犬股静脉注射后可实现满意的左室腔声学显影．如能应用到临床，将为超声心动图在冠心病室壁运动、心功能准确定量等方面提供帮助．Abstract:To investigate the efficacy of left ventricular contrast echocardiography (LVCE), 5% sonicated albumin was injected through femoral vein in 3 close—chest dogs. Results: The mean size of contrast microbubbles was 4.2±k2.4μm less than red cells. The contrast agent produced complete opacification of the right heart chambers. After 5—8 cardiac cycles, contrast effect appeared in left ventricle in all 10 injections (100%) and the contrast effect persisted 11—30 cardiac cycles. Conclusions:Successful and reproducible VLCE can be achieved after intravenous injection of sonicated albumin made in our lab. These findings could have far—reaching implications in the use of myocardial contrast echocardiography in acute and chronic ischemic syndromes in humans.

关 键 词：超声心动图 左心声学造影 犬 

分 类 号：R540.4[医药卫生—心血管疾病]