灭螺新药ML—90002的研究  

STUDY ON THE NEW MOLLUSCICIDE;ML-90002

作　　者：王锐[1] 胡家欣[1] 经广纬[1] 徐军[1] 吴秀琴[1] 张立康[1] 膝德义 周晓农[2] 戴建荣[2] 徐国余 杨佩才 胡鸿宝 

机构地区：[1]南京药物研究所,南京210009 [2]江苏省血吸虫病防治研究所 [3]南京市血吸虫病防治医院

出　　处：《中国血吸虫病防治杂志》1996年第2期91-92,共2页Chinese Journal of Schistosomiasis Control

基　　金：卫生部血吸虫病专家咨询委员会资助课题

摘　　要：本文报道了ML-90002的合成工艺改进、室内杀螺试验、小范围现场试验及急性毒性观察等,结果表明,ML-90002有较好的杀螺效果.The compound of o,o-diisopropyI-o-(2-formic ether-3-benzofurylacetonitrile-α-oximino) phosphate (ML-90002) was studied in the following aspects :I improvement of the proparation procedures;2 molluscicidal tests in laboratory;3 field trials of molluscicidal effects;4 a-cute toxicity test on mice. Results showed that the compound had good molluscicidal effects on Oncomelania snails (LC50 = 0. 44mg/L) and low toxcity to mice (LD50 = 97. 2mg/kg).

关 键 词：o o’-二异丙基-o”-(α-甲酸甲酯-3-苯骈呋喃乙腈-a-肟)磷酸酯 灭螺作用 

分 类 号：R96[医药卫生—药理学]