噻氯匹啶和阿司匹林抑制血小板聚集的对比研究  

Comparative efficacy of ticlopidine and aspirin on inhibition of platelet aggregation

作　　者：徐军[1] 高志强[1] 周春宁[1] 纵薇[1] 诸葛海鸿[1] 宫剑滨[1] 金泳清[1] 

机构地区：[1]南京军区南京总医院心血管内科,南京军区南京总医院神经内科

出　　处：《医学研究生学报》1996年第3期202-203,共2页Journal of Medical Postgraduates

摘　　要：观察了噻氯匹啶和阿司匹林对３８例高血压和冠心病以及缺血性脑血管疾病伴高凝状态患者血小板聚集功能的抑制作用。结果提示：噻氯匹啶可明显抑制ＡＤＰ诱导的血小板聚集功能，其作用强于阿司匹林，无明显副反应。Platelet aggregation induced by ADP was assessed to compare the efficacy of ticlopidine and aspirin.16 cases of hypertension,12 of coronary artery disease and 10 of cerebral ischemic disease were 1ncluded in two groups,Platelet aggregation was reduced from 69.70±16.07%to 28.15±17.89%afterfour weeks administration of ticlopidine,in aspirin group from 70.43±18.46%to 61.41±20.84%。No serious side effects were observed in both groups,It is conclued that ticlopidine has remarkable efficacy on the inhibition of platelet aggregation.

关 键 词：噻氯匹啶 阿司匹林 血小板 聚集 

分 类 号：R973[医药卫生—药品]