吡喹酮对感染血吸虫小鼠血清羟脯氨酸及肝脏虫卵肉芽肿作用的探讨  

EFFECTS OF PRAZIQUANTEL ON SERUM HYDROXYPROLINE AND HEPATIC EGG GRANULOMA IN SCHISTOSOME INFECTED MICE

作　　者：赵雪云[1] 陈静卿[1] 蒋明森[1] 苏天成[1] 

机构地区：[1]湖北医科大学寄生虫学教研室,武汉430077

出　　处：《中国血吸虫病防治杂志》1995年第3期145-148,共4页Chinese Journal of Schistosomiasis Control

基　　金：世界银行贷款的经费资助

摘　　要：本研究主要观察吡喹酮(PZQ)对血清游离羟脯氨酸(F-Hyp)水平和肝脏虫卵肉芽肿(HEG)的作用.结果显示PZQ在减轻HEG及纤维化反应的同时,还可降低F-Myp的水平,表明F-Hyp水平能够反映肝脏胶原代谢的情况,可作为血吸虫性肝纤维化(SHF)诊断和疗效判断的一个指标.This study aimed at the effect of praziquantel on the related change of serum free hy-droxyproline (F-Hyp) and hepatic egg granuloma. The results showed that praziquantel decreased the F-Hyp content as well as depressed the hepatic egg granulomatous reaction and hepatic fibrosis. It indicated that the level of F-Hyp can serve as an index of the collagen metabolism in the liver.

关 键 词：日本血吸虫 吡喹酮 胶原纤维 虫卵肉芽肿 羟脯氨酸 

分 类 号：R532.21[医药卫生—内科学]