THE DIFFERENTIATION BETWEEN N-PHOSPHORYL HOMO-SERINE AND SERINE  

作　　者：Qing Jin YAN Ying Wu YIN Qian WANG Yu Fen ZHAO 

机构地区：[1]Bioorganic Phosphorus Chemistry Laboratory,Department of ChemistTy,Tsinghua University,Beijing 100084

出　　处：《Chinese Chemical Letters》1995年第4期267-270,共4页中国化学快报（英文版）

摘　　要：Chemically, N-phosphoryl homo-serine was much more stable than the homologous compound phosphorylated serine. The latter was very reactive to undergo N -->O migration, formation of peptide and cyclophosphoroamidate but not the former when they were warmed in alcohol or chloroform at 40 degreesC. For the N-phospho-homo-serine, only a small extent of ester exchange occurred on the phosphorus. A second type of penta-coordinate phosphorus intermediate was proposed.Chemically, N-phosphoryl homo-serine was much more stable than the homologous compound phosphorylated serine. The latter was very reactive to undergo N -->O migration, formation of peptide and cyclophosphoroamidate but not the former when they were warmed in alcohol or chloroform at 40 degreesC. For the N-phospho-homo-serine, only a small extent of ester exchange occurred on the phosphorus. A second type of penta-coordinate phosphorus intermediate was proposed.

分 类 号：O613.61[理学—无机化学]