SYNTHESIS　AND　POTENTIAL　ANTINEOPLASTIC　ACTIVITY　OF　α－（1－CYCLOPENTENYL）　CYCLOPENTANONE　DERIVATIVES　－A　NEW　FAMILY　OF　ANTICANCER　AGENTS  

作　　者：Chuan Min QI(Department of Applied Chemistry,Peking Agricultural University.Peking.100094)Zhi Zhong JI(Shenyang Pharmaceutical University, Shenyang,110015) 

出　　处：《Chinese Chemical Letters》1995年第10期847-850,共4页中国化学快报（英文版）

摘　　要：In search for anticancer agents,thirteen new a, Punsaturated and β-aminomethylcyclopentanones containing α-(1-cyclopentenyl) have been synthesized by condensation and by Mannichreaction receptively.Anticancer test showed that all title compounds have significant activities againstP.Hela,HepA and EAC in vitro.Part of these compounds were shown to have activity against EACtumour in vivo.In search for anticancer agents,thirteen new a, Punsaturated and β-aminomethylcyclopentanones containing α-(1-cyclopentenyl) have been synthesized by condensation and by Mannichreaction receptively.Anticancer test showed that all title compounds have significant activities againstP.Hela,HepA and EAC in vitro.Part of these compounds were shown to have activity against EACtumour in vivo.

分 类 号：O625[理学—有机化学]