胚鼠黑质细胞分别移植于帕金森病模型鼠纹状体和侧脑室的比较研究  

A COMPARISON OF THE TRANSPLANTATION OF FETAL NIGRAL CELLS INTO THE STRIATUM AND THE LATERAL VENTRICLE OF PARKINSON'S DISEASE RATS

作　　者：刘仁刚[1] 周洁萍[1] 余达经[1] 刘云华[1] 

机构地区：[1]同济医科大学解剖学教研室

出　　处：《中国组织化学与细胞化学杂志》1995年第3期74+275-277,275-277,共4页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：胚鼠黑质细胞悬液分别移植于帕金森病（ＰＤ）鼠纹状体和侧脑室。移植后两组动物的Ａｐｏｍｏｒｐｈｉｎｅ诱导旋转行为均得到极明显改善，移植细胞生长发育良好。移植细胞和宿主细胞间的信息联系，在纹状体内可能以突触传递方式为主。侧脑室内移植的黑质细胞，相当于人工放置的“接触脑脊液神经元”，可能主要通过非实触传递方式而发挥作用。Fetal rat nigral cell suspensions were transplanted respectively into the striatum and the lateral ventricle of Parkinson's disease rats. The results showed that after transplantation the apomorphine-induced rotation behavior had a marked improvement in both groups and that the grafted cells survived and grew very well. In the striatum group, the communication of message between the grafted cells and host cells might be mainly passed by synaptic transmission. But in the ventricle group, it may be mainly passed by nonsynaptic transmission.The grafted cells in the ventricle could be regarded as the artificial ' cerebrospinal fluid-contacting neurons'.

关 键 词：黑质细胞 移植 帕金森病 纹状体 侧脑室 

分 类 号：Q253[生物学—细胞生物学]