超氧化物歧化酶抗辐射作用的临床研究  

RANDOMIZED CLINICAL RESEARCH OF ANTIRADIATION EFFECT OF SUPEROXIDE DISMUTASE (SOD)

作　　者：涂青松[1] 唐建兵[1] 申良方[1] 雷衍凡[1] 

机构地区：[1]湖南医科大学湘雅医院放疗科

出　　处：《中国现代医学杂志》1994年第3期12-13,79,共3页China Journal of Modern Medicine

摘　　要：自１９９３年７月至１９９４年４月收治了１０５例恶性肿瘤病人，采用双盲法，将病人随机分成治疗组（ＳＯＤ组）和安慰组，两组的放疗方法相同。治疗组在放疗后半小时至１小时内肌注超氧化物歧化酶（简称ＳＯＤ）；而安慰组注射安慰剂。结果显示：治疗组皮肤、粘膜、内脏器官及全身中、重度放射反应率分别为１７．５％，３８．８％，３８．８％，５０％；而安慰组分别为７６％，７６．９％，１００％，８８％，两组之间有非常显著性差异（Ｐ＜０．０１），两组之间血白细胞下降率无明显差异（Ｐ＞０．０５），治疗组有效率为６８．８％，明显高于安慰组１６％，本组未发现超氧化物歧化酶有明显的毒副作用。因此我们认为ＳＯＤ是一种安全有效的抗辐射反应的新药。Abstract From 1993 to 1994 105 patients with malignant tumors were treated. We put to use two blind method. The patients were randomized into a treatment group (SOD group) and a comfort group. The radiotherapy method in both groups were similar. The SOD group is given intramuscular injection SOD in half to an hour after radiotherapy; But the comfort group is given intramuscular injection comfort drug. The results showed middle-high degree radiation reaction rate of the skin, mucous membrance, internal organs and the whole body in the SOD group are 17. 5%、38. 8%、38.8% and 50%; in the comfort group are 76%、76. 9%、100% and 88%. There is statistically significant difference between these two groups (P<0.01). The decline rate of the white cell in the blood doesn't present statistically significant difference between these two group (P>0. 05). The effective rate of the treatment group is 68. 8%. The comfort group is 16%. There is statistically significant difference between the two groups (P<0. 005). We did not find SOD's obvious toxicity and side effect.Thence we consider that SOD is a safe and effective new drug for antiratiation effect.

关 键 词：SOD 放射治疗 辐射反应 恶性肿瘤 

分 类 号：R96[医药卫生—药理学]