Inhibitory Effects of Chlorpheniramine and Astemizolum on Contraction of Isolated Rat and Rabbit Uteri Induced by Oxytocin and PGF_(2α)  

作　　者：陈锋 侯淑贤 代宗顺 

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》1994年第3期162-164,共3页华中科技大学学报（医学英德文版）

摘　　要：The contraction of isolated rat and rabbit uteri induced by oxytocin and PGF2α was markedly inhibited by chlorpheniramine (Chl) and astemizolum (Ast) , both of which also decreased the resting tension of uteri, and their spontaneous contraction. The inhibitory effects of both drugs were dose-dependent. At high concentrations , Chl 7. 4 × 10-4 mol/L and Ast 10-4 mol/L could counteract the contraction of the uteri induced by Oxy and PGF2α, and their spontaneous contraction as well. They decreased the resting tension to the lower level. The mechanism of their non-special relaxed action on uteri could not be completely explained only by their H1-receptor blocking action. Whether they act by blocking calcium channel or by inhibiting calmodulin (CaM) remains to be further explored.The contraction of isolated rat and rabbit uteri induced by oxytocin and PGF2α was markedly inhibited by chlorpheniramine (Chl) and astemizolum (Ast) , both of which also decreased the resting tension of uteri, and their spontaneous contraction. The inhibitory effects of both drugs were dose-dependent. At high concentrations , Chl 7. 4 × 10-4 mol/L and Ast 10-4 mol/L could counteract the contraction of the uteri induced by Oxy and PGF2α, and their spontaneous contraction as well. They decreased the resting tension to the lower level. The mechanism of their non-special relaxed action on uteri could not be completely explained only by their H1-receptor blocking action. Whether they act by blocking calcium channel or by inhibiting calmodulin (CaM) remains to be further explored.

关 键 词：chlorpheniramine (Chl) astemizolum (Ast) oxytocin (Oxy) PGF_(2α) uterus contraction inhibiting calmodulin (CaM) 

分 类 号：R96[医药卫生—药理学]