INVESTIGATION ON INACTIVATED EPIDEMIC HEMORRHAGIC FEVER TISSUE CULTURE VACCINE IN HUMANS  

作　　者：朱智勇 唐汉英 李岩金 翁景清 俞永新 曾蓉芳 

机构地区：[1]ZhejiangProvincialHygieneandEpidemicPreventionStation [2]NationalInstitutefortheContuolofPharmaceuticalandBiologicalProducts [3]ShanghaiInstituteofBiologicalProducts [4]buttheresultsbyreversedpassivehemagglutination(RPHI),immunofluoresceuceassay(IFA)andELISAweresimilar.Differentimmunizationproce-

出　　处：《Chinese Medical Journal》1994年第3期9-12,共4页中华医学杂志（英文版）

摘　　要：From 1988 to 1992, 2479 volunteers were immunized by inactivated Meriones unguiclatus kidney cell (MUKC) vaccine.Their seroconversion rates of neutralizing antibody were about 90% after 3 doses of the vaccine. No side effects were found.The vaccine stored for 14 months at 4℃ still had good immnogenicity. It was shown that the vaccine was safe, effective and stable. Detailed observation was made in 75 volunteers. The results showed that the seroconversion rate by plaque reduction neutralization test in 3 doses group was higher than that in 2 doses group; but the results by reversed passive hemagglutination (RPHI),immunofluoresceuce assay (IFA) and ELISA were similar. Different immunization proce-

分 类 号：R512.8[医药卫生—内科学]