氟桂嗪防治新生大鼠缺氧缺血性脑病效果观察  

THE EFFECTS OF FLUNARIZING IN THE HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN THE INFANT RAT

作　　者：徐放生[1] 吴婉芳[1] 张莉莉[1] 蔡玲玲[1] 张梓荆[1] 

机构地区：[1]首都儿科研究所

出　　处：《中国新生儿科杂志》1994年第6期267-269,288-263,共5页Chinese Journal of Neonatology

摘　　要：99只新生大鼠缺氧缺血性脑病模型随机分为三组。预防组和治疗组分别于缺氧缺血前、后给予氟桂嗪，观察各组模型的行为改变、脑含水量、脑大体和显微镜下改变。预防组脑含水量88．34±1．12％，明显低于对照组的90．38±2．24％（P＜0．005），脑大体改变和显微镜下改变也比对照组明显减轻（P＜0．001和P＜0．01）。治疗组各项检查虽有减轻，却无显著性差异（P＞0．05）。本实验表明氟桂嗪能减轻新生大鼠缺氧缺血性脑损伤。Ninety-nine newborn rats were divided randomly into three groups in the research of hypoxic-ischemic encephalopathy. The preventive and treatment groups were given flunarizing orally before and after hypoxic-ischemic damages, respectively. The behavior, brain water content, morphologic and histologic changes were examined. Water content in preventive group was 88.34±1.12%,much lower than 90.38±2.24% of control group (P<0.005).Morphologic and histologic changes were much lesser in the preventive group than that of control groug (P<0.001 and P<0.01). All damages were lesser in treatment group than control group but without statistically significant difference (P>0.05). These observations confirmed that flunarizing has a neuroprotective effect against hypoxic-ischemic injury in the developing brain.

关 键 词：氟桂嗪 缺氧缺血性脑病 

分 类 号：R722.12[医药卫生—儿科]