围产期窒息与β-内啡肽关系的研究  

THE POSSIBLE RELATIONSHIP TO PERINATAL ASPHYXIA AND β-ENDORPHIR

作　　者：曹蕾[1] 钱培德[1] 梁秋谨 张琳[1] 亓蓉[2] 乔艳霞 刘桂兰 

机构地区：[1]河北省人民医院儿科 [2]石家庄市妇产医院

出　　处：《中国新生儿科杂志》1994年第1期6-7,46-47,共4页Chinese Journal of Neonatology

摘　　要：本文用放免法测定44例窒息新生儿血浆β－内啡肽（β－EP）的变化，同时测定31例正常新生儿为对照组。结果表明，窒息新生儿组血浆β－EP明显高于对照组，并发现血浆β－EP水平与Apgar评分密切相关，严重窒息组比中度窒息组血浆β－EP明显增高。在窒息组中有宫内窘迫者血浆β－EP水平高于无窘迫者，提示β－EP在围产期窒息的发病机制中起一定作用，对其治疗推荐用纳洛酮。The radioimmunoreactive assay of β-endorphin - like - immunoreactivity was used to investigate changes of plasma β-endorphir in 44 asphyxiated neonates. 31 healthy neonates were taken as controls. The results showed that plasma β-endorphin levels in asphyxiated neonates were significantly higher than controls value. A statistically significant correlation was observed between plasma β-endorphin and Apgar scores. Severe asphyxiated infants had significantly higher plasma β-endorphin compared with moderate asphyxiated infants.Plasma β-endorphin levels was higher in asphyxiated neonates with fetal distress comparing with asphyxiated neonates without fetal distress. These results suggest that β-endorphin may play a role in the pathophysiology of perinatal asphyxia and possible therapeutic role of naloxone in the therapy of the perinatal asphyxia should be investigated

关 键 词：围产期窒息 血浆Β-内啡肽 

分 类 号：R722.12[医药卫生—儿科]