糖尿病和冠心病患者血中脂质过氧化物及内皮素的变化  

Changes of blood lipid peroxide and endothelin in patients with coronary heart disease and diabetes mellitus

作　　者：洪天配[1] 郭志军[1] 张路[1] 刘晨[1] 毛节明[1] 李琼芳[1] 

机构地区：[1]北京医科大学第三医院

出　　处：《中国糖尿病杂志》1994年第4期211-214,共4页Chinese Journal of Diabetes

基　　金：卫生部科学基金

摘　　要：测定了１８例冠心病患者、１７例糖尿病患者、１６例糖尿病冠心病患者和２０例健康对照者血清脂质过氧化物（ＬＰＯ）水平、超氧化物歧化酶（ＳＯＤ）活性以及血浆内皮素（ＥＴ）含量。两组冠心病患者均有过心肌梗塞病史。冠心病组和糖尿病组ＬＰＯ水平、ＬＰＯ／ＳＯＤ比值和ＥＴ含量明显高于对照组，糖尿病冠心病组又显著高于冠心病组和糖尿病组。ＬＰＯ／ＳＯＤ比值与ＥＴ含量呈正相关。结果表明ＥＴ与脂质过氧化损伤之间相互作用在糖尿病患者冠心病的发生和发展中具有重要作用。Serum lipid peroxide(LPO) level, superoxide dismutase (SOD) activity and plasma endothelin (ET) value were determined in 18 patients with coronary heart disease(CHD),17 patients with diabetes mellitus,16 diabetic patients with CHD, and 20 control subjects. There existed history of myocardial infarction in groups of patients with CHD and diabetic patients with CHD. The LPO level,LPO/SOD ratio and plasma ET value were significantly higher in the patients with CHD and the patients with diabetes mellitus than those in the control subjects. The increases of the biochemical parameters mentioned above were more pronounced in the diabetics with CHD than in the other two groups of patients, There was significant correlation between LPO/SOD ratio and ET value in all the groups of patients and control subjects.Our results suggest that the interplay between ET and lipid peroxidation might play an important role in the development and exacerbation of CHD in diabetics.

关 键 词：糖尿病 冠状动脉疾病 脂质过氧化物 内皮素 

分 类 号：R587.1[医药卫生—内分泌]