水飞蓟宾、槲皮素对糖尿病鼠主动脉胶原和血清β脂蛋白非酶糖化的阻断作用  

The blocking effects of silybin and quercetin on the nonenzymatic glycosylation of aortic collagen and serum β-Lp in experimental diabetic rats

作　　者：葛勇[1] 张家庆[1] 周云平[1] 

机构地区：[1]第二军医大学长海医院内分泌科

出　　处：《中国糖尿病杂志》1994年第1期38-41,共4页Chinese Journal of Diabetes

摘　　要：中药用于糖尿病及其并发症的预防和治疗的确切机理尚不清楚。本文发现链脲菌素引起的糖尿病大鼠模型，８周后主动脉胶原（ａｄｖａｎｃｅｄｇｌｙｃｏｓｙｌａｔｉｏｎｅｎｄｐｒｏｄｕｃｔｓ，ＡＧＥ）荧光强度、胶原含量、糖化血清β脂蛋白（β－Ｌｐ）均明显增加，Ｐ＜０．０１。分别给予水飞蓟宾、槲皮素１００ｍｇ·ｋｇ－１／ｄ，治疗８周后，发现血糖无明显降低。而大鼠主动脉胶原及胶原ＡＧＥ含量、血清糖化β－Ｌｐ含量均有明显降低并接近正常。揭示水飞蓟宾。The precise mechanisms of Chinese herbaceous medicines in the prevention and treatment of diabetes have not been elucidated so far.In this report,we found that in streptozotocin-induced diabetic rats, the blood glucose,aortic collagen, advanced glycosylation endproducts(AGE),serum glycated β-Lp were significantly elevated in comparison with normal rats(P<0.01).Oral silybin and quercetin(100mg/kg-1·d) for eight weeks dramatically reduced aortic collagen AGE,and serum glycated β-Lp levels without affecting blood glucose level.It suggests silybin and quercetin have marked inhibiting effect on nonenzymatic glycosylation of animal tissue proteins.

关 键 词：糖尿病 实验性 

分 类 号：R587.1[医药卫生—内分泌]