急性低气压性缺氧对小鼠心电活动的影响  

EFFECTS OF ACUTE LOW AIR-PRESSURE ON CARDIOELECTRIC ACTIVITY OF MICE

作　　者：吴伟康[1] 易慧智[1] 罗汉川[1] 尧宏斌[1] 侯灿[1] 

机构地区：[1]中山医科大学病理生理学教研室

出　　处：《高原医学杂志》1994年第3期17-19,共3页Journal of High Altitude Medicine

摘　　要：本文研究了低气压环境下小鼠心电活动的特点，并以心电活动时间（ＣＥＡＴ）为指标，观察了不同气压、增龄、药物对小鼠心电活动的影响。结果发现：随气压下降，ＣＥＡＴ缩短；随增龄，ＣＥＡＴ缩短；冬眠灵、三磷酸腺鲁可延长ＣＥＡＴ，而肾上腺素则显著缩短ＣＥＡＴ。上述结果提示：缺Ｏ＿２越严重，ＣＥＡＴ越短；老化可削弱心脏对缺Ｏ＿２的耐受力，降低氧耗或／和增加能量供应，可增强心脏对缺Ｏ＿２的耐受，反之则损害心肌的电活动。同时，还提示用ＣＥＡＴ来反映小鼠心脏对缺Ｏ＿２的耐受性，具有客观、定量、准确、灵敏的特点。he characters of cardioelectric activity of mice under air-pressure were studied,and the ef- fects of various air-pressure environments,aging and drugs on cardioelectric activity of micewere observed by measuring cardioelectric activity time(CEAT). The results indicate that with the decline of air-pressure,CEAT became shortened;withaging,CEAT became shortened too;reducing oxygen consumption or/and increasing supply ofenergy could strengthen the tolerance to hypoxia;conversely,cardioelectric activity will be dis- turbed,and that utilizing CEAT to measure ability of heart to resist hypoxia has the characters ofobjectivity,quantitation and accuracy.

关 键 词：低气压 缺氧 小鼠 心脏 心电图 

分 类 号：R594.3[医药卫生—内科学]