阿尼玛卿山高原鼠兔肾组织化学观察  

OBSERVATION OF HISTOCHEMISTRY FOR KIDNEY OF ALTITUDE PIKA AT MT. ANIMAQING

作　　者：苏明华[1] 温佳林 王志刚[1] 陈华伟[1] 火克信 寇星灿 

机构地区：[1]青海省高原医学科学研究所,中国医学科学院卫生学校

出　　处：《高原医学杂志》1994年第3期20-22,共3页Journal of High Altitude Medicine

摘　　要：本文报告了用组织化学的方法，测定生活在阿尼玛卿山（海拔４５００ｍ）高原鼠兔与生活在平原（北京）的Ｗｉｓｔａｒ大鼠肾脏中ＡＴＰａｓｅ，ＳＤＨ，ＬＤＨ，ＡＬＰ和ＡＣＰ的活性及定位，对比观察的结果发现：①ＡＴＰａｓｅ的定位及活性在鼠兔和大鼠之间有明显差异，鼠兔的ＡＴＰａｓｅ主要定位在肾小管上皮，大鼠主要定位在肾小体上；②鼠兔的ＡＣＰ活性较弱，定位在肾小体和肾小管上皮；而大鼠只定位在肾小管上，活性稍强；③ＳＤＨ和ＡＬＰ都定位在肾小管上，但鼠兔的ＳＤＨ活性显示较高，而ＡＬＰ活性在大鼠中较高；④ＬＤＨ的定位与活性两者完全相似，作者对高原鼠兔在低氧环境中肾脏梅系统的变化特征及适应机制作了初步探讨。he activities and locations of ATPase,SDH,LDH, ALP and ACP in kidneys of altitudepikas living at Mt.Animaqing(4 500m)and Wistar rats living at plain(Beijing) had been mea- sured by histochemical methods. The results of constract observation were showed as follows:1.The activities and localizations between Pikas and rats were significant differences,however,the ATPase of pikas was mainly oriented on renal tubular epithelia, but rats on renal corpuscles. 2. The ACP activity of pikas was weaker which was oriented on renal tubular epithelia andcorpuscles,but the activity in rat was stronger on renal tubules only. 3. The SDH and ALP were all located on renal tubules,SDH activity of pikas showed higher,and ALP of rats too. 4. The activity and orientation of LDH in both were similar completely. Authors approach initially that the enzyme system of kidney in altitude pika appears changedcharacteristics and mechanisms under bypoxia.

关 键 词：高原鼠兔 肾 SDH 低氧 

分 类 号：R594.3[医药卫生—内科学]