高原居民超氧化物岐化酶和过氧化脂质的测定  

A STUDY ON RELATIONSHIP BETWEENCHANGES OF SOD, LPO AND SENILISM IN PERSONS AT MEOIUM ALTITUDE

作　　者：张鑫生[1] 刘丽萍[1] 郭雪微[1] 阿祥仁[1] 

机构地区：[1]青海省人民医院老年病研空室

出　　处：《高原医学杂志》1994年第1期18-20,共3页Journal of High Altitude Medicine

摘　　要：对海拔２２６０ｍ的西宁地区６００名不同年龄健康人进行了红细胞─—超氧化物歧化酶（ＳＯＤ）和过氧化脂质（ＩＰＯ）测定，并与平原同龄人的测值进行了对比分析。结果表明；①高原与平原居民均随着增龄而表现出ＳＯＤ活性降低，ＬＰＯ升高。②在各年龄组中，高原居民ＳＯＤ活性明显低于平原同龄人（Ｐ＜０．０１），而血清ＬＰＯ含量显著升高（Ｐ＜０．０１）。③与平原测值比较，随着增龄高原居民ＳＯＤ活性降更明显，ＬＰＯ升高的幅度也增加。上述改变表明了长期生活在低氧环境下的高原居民体内存在有自由基代谢失衡，这可能是高原人早衰的重要原因之一。e measured the level of lipid peroxide(LPO)and superoxide dismutase(SOD)in the healthypersons of different age in Xining(2 260m)and compa red with the value of same age persons atsea level(Xian).The results showed that 1. the level of SOD decreased and LPO in creased withaging at both plateau and lowland;2. the level of SOD in persons at high altitude was significantlylower(P<0.01)and LPO was Markedly highr(P<0. 01)and LPO was Markedly higher(P<0. 01)than persons at plain in each group;3. when compared with lowland , the decrease of SODand in crease of LPO with aging at highland were more significantly.It suggested that themetabolism of free radica in persons who lived inhypoxic environment at plateau was imbalance itmight be the one of important reasons,in senitism at high altitude.

关 键 词：高原居民 超氧化物歧化酶 过氧化脂质 

分 类 号：R594.3[医药卫生—内科学]