吡喹酮肌肉注射制剂治疗实验感染家兔和牛日本血吸虫病  

INTRAMUSCULAR PREPARATION OF PRAZIQUANTEL FOR TREATING SCHISTOSOMIASIS JAPONICA OF ARTIFICIALLY INFECTED DOMESTIC RABBITS AND WATER BUFFALO

作　　者：施福恢[1] 沈纬[1] 钱承贵[1] 林邦发[1] 张正达[1] 叶萍[1] 汪英华[1] 田锷[1] 石跃军 朱顺海[1] 张军[1] 严汉英[2] 朱延勤[2] 刘学丽[2] 王正佑 杨正风 

机构地区：[1]中国农业科学院上海家畜寄生虫病研究所,上海200032 [2]南京药物研究所 [3]上海兽药厂

出　　处：《中国血吸虫病防治杂志》1994年第2期92-95,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家"八五"攻关专题部分工作

摘　　要：本文报道吡喹酮肌肉注射制剂治疗实验感染家兔、水牛血吸虫病的杀虫效果、血药浓度和组织病理学变化的结果.10%肌注剂15和25mg/kg治疗水牛血吸虫病的减雌率均为100%,减虫率为59.2%及81.9%.制剂无副作用,使用方便.血药浓度测定30mg/kg肌注组注射后0.5h达1297μg/ml,是同剂量口服组的3.7倍,是15mg/kg肌注组的3倍.并就肌注剂杀灭雌虫的意义及作用机制进行了讨论.The present article reported the therapeutic effects of Praziquantel administred intra-muscularly to experimentally infected domestic rabbits and water buffalo with Schistosoma japonicum by means of special reference to effective blood concentration and histopathology. The female worm reduction in water buffaloes using 10% Praziquantel preparation i. m. at 15-15mg/kg were 100% while worm reduction was 59. 2%-89. 2%.The preparation was safe,without side effects,easy to handle and administer. The drug concentration in blood of the group with 30mg/kg i. m. was l 300μg/ml at 0.5 h,which was two times as high as that of the same dosage per os, and three times as high as that of the 15 mg/kg i. m.

关 键 词：日本血吸虫病 治疗 吡喹酮 牛 

分 类 号：S859.79[农业科学—临床兽医学]