猪胃螺杆样细菌与幽门螺杆菌的比较研究  

OMPARISON OF HELICOBACTER-LIDE ORGANISMS IN PIGS TO HELICOBACTER PYLORI

作　　者：陈晶晶[1] 张建中[1] 姚楚铮[1] 蒋秀高[1] 刁保卫[1] 庄弢[1] 

机构地区：[1]中国预防医学科学院流行病学微生物学研究所

出　　处：《中国微生态学杂志》1994年第1期20-24,共5页Chinese Journal of Microecology

摘　　要：我们检测１０例普通猪的胄组织，有８例分离到螺杆菌样细菌（ＨＬＯ）。其菌落、菌体形态和某些生化反应与幽门螺杆菌（ＨＰ）相似，但其尿素酶活性较低，ＨＬＯ全菌蛋白的ＳＤＳ一ｐＡＧＥ图谱也与ＨＰ的不同。本文就ＨＰ和ＨＬＯ及其伴发的人、猪慢性胃炎的特点，作了比较和讨论。elicobacter-like organisms(HLO)were isolated from 8 out of 10 stomachs of conventional normal pig.The morphology and some bioche-mical reactions of HLO were similar to that of Helicobacter pylori(HP),while the urease activity of HLO were lower than that of HP. SDS-PAGE analysis of whole cell proteins of HLO were not identical with that of HP. In addition to HLO colonzation,Pathological clianges were observed in gastric mucosa, including antral and cardia regions. Micro-scopically,there were focal to diffuse chronic inflammatory lesions with mild to moderate infilration of mononuclear cells, plasma cells and few neutrophiles. With the Warthin-starry stain, Organisms were seen in the mucus layer and on the surface of the gastric epithelial cells beneth the mucus layer. Our data indicate that,HLO in pigs, as HP in humans,in an important causal agent in the pathogenesis of chronic gastritis.

关 键 词：慢性胃炎 幽门螺杆菌 螺杆菌样细菌 

分 类 号：R378.99[医药卫生—病原生物学]