Relative reactivities of bromine-substituted substrates toward bromophilic attack by a carbanion  

作　　者：LI,Xing-Ya JIANG,Xi-Kui ZHANG,Xiao-Jun Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032 

出　　处：《Chinese Journal of Chemistry》1992年第2期186-188,共0页中国化学（英文版）

基　　金：the National Natural Science Foundation of China.

摘　　要： Halophilic attack on carbon-halogen bond by nucleophiles has recently become a sub-ject of interest and intensive study.A wide variety of substrates and nucleophiles has beenexamined.But no quantitative measurements on the reactivities of substrates have ever beenreported.The present work is a first attempt to evaluate the relative reactivities of perfluoro-bromoalkanes（R-Br）and some bromo organic compounds（R-Br）by intermolecular compe-tition kinetics.A large excess of ClCCFCFCl（1）,a chlorine-containing substrate withconvenient reactivity toward halophilic attack,and R-Br is used to compete for a small amountof the enolate anion of mesityl isopropyl ketone（E-）in dimethyl formamide（DMF）at 20℃in their reactions to form α-chloroisopropyl mesityl ketone（A）and α-bromoisopropylmesityl ketone（B）as products（eq 1）

关 键 词：rate Br CCF 

分 类 号：O6[理学—化学]