Asymmetric syntheses of α-amino acids via double chiral induction in alkylation of the ketimine derived from 2-hydroxypinan-3-one and menthyl glycinate  

作　　者：MI, Ai-Qiao MA, Zeng-Xin WU, Lan-Jun JIANG, Yao-Zhong Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610015 

出　　处：《Chinese Journal of Chemistry》1992年第5期434-438,共0页中国化学（英文版）

基　　金：the National Natural Science Foundation of China.

摘　　要：Asymmetric syntheses of (S)-α-amino acids in 28--98% optical yields via double chiral induction in alkylations of ketimine 1 derived from (+)-2-hydroxypinan-3-one and (-)-men- thyl glycinate which is a chiral match pair have been studied. The factors controlling the diastereoselec- tivities in alkylation reactions of the ketimine, the properties of alkylating agents and various alkylation conditions are examined.Asymmetric syntheses of (S)-α-amino acids in 28--98% optical yields via double chiral induction in alkylations of ketimine 1 derived from (+)-2-hydroxypinan-3-one and (-)-men- thyl glycinate which is a chiral match pair have been studied. The factors controlling the diastereoselec- tivities in alkylation reactions of the ketimine, the properties of alkylating agents and various alkylation conditions are examined.

关 键 词：Asymmetric syntheses of amino acids via double chiral induction in alkylation of the ketimine derived from 2-hydroxypinan-3-one and menthyl glycinate 

分 类 号：O6[理学—化学]