HIGHLY REGIOSELECTIVE O-AND N-ACYLATION OF 5-METHYL-3-HYDROXYISOXAZOLE  

作　　者：Rui Lian SHAO Cheng Xin ZHI You Quan ZHU Jie You XUE 

机构地区：[1]National Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071.

出　　处：《Chinese Chemical Letters》1992年第3期175-176,共2页中国化学快报(英文版)

基　　金：This project was supported by the NSFC.

摘　　要： Acylation of 5-methyl-3-hydroxyisoxazole (1) with 3-substituted cyclopropanecarboxylic chlorides (3) in the presence of triethylamine (TEA) in acetonitrile yields predominantly O-acylated products (4).The N-acyl isomers (5) are afforded regiospecifically using trimethylsilyl ether of 3-hydroxyisoxazole (2).Acylation of 5-methyl-3-hydroxyisoxazole (1) with 3-substituted cyclopropanecarboxylic chlorides (3) in the presence of triethylamine (TEA) in acetonitrile yields predominantly O-acylated products (4).The N-acyl isomers (5) are afforded regiospecifically using trimethylsilyl ether of 3-hydroxyisoxazole (2).

关 键 词：HIGHLY REGIOSELECTIVE O-AND N-ACYLATION OF 5-METHYL-3-HYDROXYISOXAZOLE TEA 

分 类 号：O6[理学—化学]