发酵虫草降胆固醇作用机理的初步研究  

Mechanism of the Hypocholesterolemic Effect of CsB-851 (a Fraction Separated from Fermented Mycelium of CordycepS Sinensis) in Mice

作　　者：李林[1] 包天桐[1] 宋振玉[1] 

机构地区：[1]中国医学科学院药物研究所,北京100050

出　　处：《中药药理与临床》1992年第2期6-10,共5页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：人工发酵虫草菌丝体有效部分CsB-851能使正常及高脂小鼠血清总胆固醇分别降低10～20％及25～47％。以〔2-(14)C〕-乙酸钠为前体进行参入实验,发现CsB-851使参入小鼠肝胆固醇(游离和酯化胆固醇)的放射性明显减少,但不影响对外源性胆固醇的吸收与排出。提示其降低血胆固醇的主要机制在于抑制肝胆固醇的合成。Cordyceps sinensis (Cs) is a famous Chinese traditional medicine. The ethanol ext-fact of fermented mycelium, CsB, has been reported to be hypolipidemic.Our experim-ents showed that CsB-851, a fraction, separated from CsB, was 5-10 times more active in lowering blood cholesterol than CsB both in normal and in tritpn-treated hyperlipid- emic mice. The serum total cholesterol level was shown to be reduced 10-20% in normal mice and 25-47% in triton Indued hyperlipidemie mice after sc injection of 100-400mg 80/kg. Incubation of sodium acetate-2-14C with liver S10 preparaton from triton-treated mice, showed that the incorperation of radioactivity into liver cholesterol was significa-utly reduced (approximately 50% ) by the treatment with CsB-851. No change in chole-sterol absorption and little increase in: fecal neutral steroids excretion in normal mice were observed after subeutaneous injection of CsB-351 200mg/kg. This suggests that the probable meahanism of the hypocholesterolemic action of CsB-851 is the inhibition of eholesterol biosynthesis,in liver.

关 键 词：冬虫夏草 胆固醇 〔2-¹⁴C〕-乙酸钠 

分 类 号：R28[医药卫生—中药学]