黄芪、当归及其配伍对大鼠血小板聚集和血小板中cAMP、cGMP的影响  

Effects of Radix Angelicae Sinensis, Radix Astragali and their compatiblities on Platelet aggregation and changes of cAMP and cGMP in platelet

作　　者：吴建新[1] 蒋莹[1] 严永清[1] 

机构地区：[1]中国药科大学中药学院,南京210009

出　　处：《中药药理与临床》1992年第1期16-17,22,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：黄芪、当归二个单味药的研究有较多报道,但对黄芪配伍当归这一著名药对的研究却不多。本文试图通过黄芪、当归及其配伍对血小板聚集、血小板中cAMP、cGMP的影响来研究补气药黄芪、补血药当归的配伍意义,并以这些指标来观察黄芪、当归及其成分在药理作用方面的异同。 实验材料 一、仪器 SPA—4型血小板聚集仪（上海科达测试仪器厂）、LKB1275r测定仪。 二、试剂 ADP为Sigma产品,¹²⁵I-cAMP、¹²⁵I-cGMP药盒由上海中医学院同位素室提供。 三、动物 SD大鼠,雄性,300±20g,由上海医科大学动物房提供。 四、药物 AM（100％黄芪水煎液）,AM-ASⅡ（各含50％的黄芪和当归水煎液）,AS(100％AM, AM-AS Ⅱ 、 AS have action of inhibiting platlet aggregation significantly in rats. AM-AS Ⅱ and AS can inhibit in vitro thrombosis in rats clearly. AM and AS have significant synergistic actions of inhibiting platelet aggregation and in vitro thrombosis. AM has tendency of increasing the content of cAMP in platelet, AM, AM-AS Ⅱ, AS, FA, APS can decrease markedly the content of cGMP in platelet and increase the rate of cAMP/cGMP clearly. Results stated above may confirm that Qi in motion rendering blood circulation in TCM has its scientific basis and the compatibility of drugs of nourishing Qi and enriching blood has its meaning.

关 键 词：大鼠 血小板聚集仪 同位素室 药理作用 水煎 药对 补血药 环核苷酸 上海中医学院 动物房 

分 类 号：R28[医药卫生—中药学]