补中益气汤的药理作用研究——抗胃粘膜损伤机理探讨  

Study on Pharmacological Effects of Buzhong Yiqi Decoction(BZYQD)——Mechanisms of BZYQD on Preventing Gastric Mucosa Damaged

作　　者：张永锋[1] 王汝俊[1] 傅定中[1] 邵庭荫[1] 

机构地区：[1]广州中医学院脾胃研究室,届硕士研究生51040792

出　　处：《中药药理与临床》1992年第6期1-3,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局资助项目No.89233

摘　　要：先前的工作表明补中益气汤对多种胃粘膜损伤模型有良好的保护作用,本文观察了该方对胃粘膜细胞能量代谢的ATP-Na^+-K^+-Mg^(++)-ATPase-ADP系统和ADP-腺苷酸环化酶-cAMP系统平衡的调节作用。This paper has reported the pharmacological mechanisms of BZYQD on preventing gestric mucosa damaged. The results were following: ( 1 ) BZYQD could activate Na+-K+-Mg++-ATPase activity from rat gastric mucosa, and relieve that Na+-K+-Mg++-AT-Pase activity from gastric mucosa of Indomethacine-induced rat ulcer model was inhibited. ( 2 ) There was no distinct effect of BZYQD on the amounts of cAMP in normal rat gastric mucosa.but it resisted that amounts of cAMP in gastric mucosa of Indomethacine-induced rat ulcer model was decreased. The results mentioned above suggest that: The regulatory effect of BZYQD between ATP-Na+-K+-Mg++-ATPase-ADP system and ATP-adenylate cyclase-cAMP system is one of the important pharmacological mechanisms of BZYQD on preventing gastric mucosa damaged.

关 键 词：补中益气汤 胃粘膜 Na⁺-K⁺-Mg⁺⁺-ATPase 环-磷酸腺苷 

分 类 号：R28[医药卫生—中药学]