四君子汤抗自由基损伤的研究  

Pharmacological Research of Si Juln Zi Tang on Antagonising Free Radical Injury

作　　者：孙云[1] 龚跃新[1] 李瑞琴 林安平[1] 

机构地区：[1]扬州医学院,225001

出　　处：《中药药理与临床》1992年第4期1-3,6,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：本文观察了四君子汤对臭氧(O_3)造成的自由基损伤的实验性衰老模型的影响。结果显示:四君子汤能明显改善衰老模型出现的体力下降、御寒能力和对缺氧的耐受力降低,并降低脂质过氧化物(LPO)含量和脑B型单胺氧化酶(MAO-B)活力,升高血清超氧化物歧化酶(SOD)活力。证明四君子汤具有抗自由基损伤的功能,能延缓衰老。This article deals with free radical injury model induced by ozone and the anti-aging effect of Si Juin Zi Tang. The results showed that, in model group, physical st~ renth, the ability of cold-resistant and hypoxia-resistant were reduced; the lipid peroxides (LPO) content in plasma, brain, liver and the MAO-B activity of brain were increased; the SOD activity of serum was decreosed as compared witn Model group. these changes were the same with that in old age mice. Si Juin Zi Tang ( 6 , 12g/kg po) could emeliorate these changes induced by ozone. It was shown that Si Juin Zi Tang possessed the effect of antagonising free radical injury.

关 键 词：四君子汤 抗自由基损伤 抗衰老 脂质过氧化物 B型单胺氧化酶 超氧化物 歧化酶 

分 类 号：R28[医药卫生—中药学]