血吸虫病患者外周血单核细胞体外诱生IL—1水平的变化  

CHANGES OF LEVEL OF IL-1 PRODUCED BY PERIPHERAL BLOOD MONOCYTES IN PATIENTS WITH SCHISTOSOMIASIS JAPONICA IN VITRO

作　　者：李祖进[1] 罗端德[1] 吴新星 杨青[1] 曾令兰[1] 李淑莉[1] 杨业翔 王厚成 戴家珠[1] 王心禾[1] 

机构地区：[1]同济医科大学附属协和医院传染病教研室 [2]湖北省黄陂县血吸虫病防治站 [3]湖北省江陵县血吸虫病防治站

出　　处：《中国血吸虫病防治杂志》1992年第1期8-11,共0页Chinese Journal of Schistosomiasis Control

基　　金：湖北省自然科学基金

摘　　要：检测了17例急性血吸虫病(急血)、14例慢性血吸虫病(慢血)和19例晚期血吸虫病(晚血)患者外周血单核细胞体外经脂多糖(LPS)诱生白细胞介素1(IL-1)的水平。结果急血组明显升高,且与体温呈正相关;慢血组和晚血组均显著下降,以晚血组尤为显著。经消炎痛阻断前列腺素合成,3组患者的IL-1水平均显著提高,而正常对照组无明显变化。表明IL-1在介导急血患者发热和炎症反应以及慢血感染阶段的免疫调节中可能起重要作用。血吸虫病中IL-1活性的改变可能与前列腺素关系密切。Activity of IL-1 produced by peripheral blood monocytes stimulated with lipopolysaccharide in vitro was detected from 17 acute cases, 14 chronic cases and 19 advanced cases of schistosomiasis japonica. It was found that the level of IL-1 was significantly increased and positively related to the body tempereture in the group with acute schistosomiasis. The activity of IL-1 was statistically reduced in the chronic and advanced groups, especially in the latter. After inhibiting the synthesis of prostaglandin with indomethacin, the level of IL-1 was significantly increased in three groups of patients, but no apparent change in the normal contro group. The results indicate that IL-1 may play an important role in inducing the inflammatory reaction in patients with acute schistosomiasis japonica and in the immunoregulation in the chronic stage. The changes of IL-1 activity in patients with schistosomiasis japonica may be closely related to prostaglandin.

关 键 词：血吸虫病患者 IL 外周血单核细胞 慢性血吸虫病 晚期血吸虫病 前列腺素 血吸虫感染 体外诱生 免疫调节 白细胞介素 

分 类 号：R532.21[医药卫生—内科学]