支气管哮喘炎性反应的组织学证据——支气管粘膜的超微结构观察  

EVIDENCE FOR INFLAMMATION IN ASTHMA——ULTRASTRUCTURE OBSERVATION ON BRONCHI MUCOSA

作　　者：杨俊杰[1] 牛宪忠[1] 李明发[1] 高超[1] 龙沛然[2] 曾子安[2] 

机构地区：[1]成都军区昆明总医院,650032 [2]成都军区军事医学研究所昆明研究室

出　　处：《西南国防医药》1992年第4期193-195,254+258,共5页Medical Journal of National Defending Forces in Southwest China

摘　　要：为确定支气管哮喘患者支气管粘膜的组织学特征和炎性反应的程度,我们对5例哮喘病人和3例非哮喘对照病人经支纤镜取支气管粘膜进行超微结构检查。发现哮喘病人支气管粘膜固有层嗜酸性细胞浸润,支气管上皮细胞脱落,上皮基底膜增厚和裸露,纤毛上皮细胞脱落,上皮基底膜下胶原沿着和杯状细胞增生。我们的结果提示支气管哮喘气道内有广泛的炎性改变,支持支气管哮喘是一种炎性疾病的观点。We Have undertaken ultrastructureal examination of bronchial biopsis from asthmatic patients in order to determine the histologic feature of bronchial mucosa and degree of the inflammatory process in bronchial asthma. Five mild asthmatic patients and three nonasthmatic subjects underwent fiberoptic bronchoscopy. We have found in asthmatic subjects, but not in nonasthmatics, there Were lamina propria infiltration of mucosa by eosinophils, bronchial epithelial dirruption, epithelial basement membrane thickening and disrobing, shedding of the ciliated epithelium, deposition of collagen beneath the epithelial basement membrane,and goblet cell hyperplasia. Those results suggest that bronchial asthma is accompanied by extensive inflammation in the airways and support the view that bronchial asthma is an inflammatory disease.

关 键 词：支气管哮喘 支气管粘膜 超微结构 

分 类 号：R82[医药卫生—临床医学]