西藏病毒感染性腹泻三间分布的流行病学研究  

STUDIES ON VIRAL ETIOLOGY OF INFECTIOUS DIARRHEA IN TIBET

作　　者：马峰[1] 武际富 汪晓辉 郭安荣[1] 李有明 欧成德 张保同 石泉贵 赵新华[6] 

机构地区：[1]成都军区军事医学研究所,610061 [2]西藏军区防疫队 [3]75医院 [4]8医院 [5]41医院 [6]西藏自治区人民医院

出　　处：《西南国防医药》1992年第S1期15-17,87,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：1990年5月-1992年4月对西藏自治区六个地区1557例腹泻患者粪便标本作了WHO规定方法的调查,经ELISA、SDS—PAGE和EM技术,结果检出四种 (487份) 与腹泻有关的肠道病毒,总阳性率31.28％,其中HRV为26.33％ (410/1557);Edes为3.08％ (48/1557);Reor为1.09％ (17/1557);SRvs为0.77％ (12/1557)。HRV感染冬春占65.76％,夏秋占34.24％;月龄儿占44.18％,3岁组占39.22％,5岁组占82.39％,6岁以上占19.31％。HRV—RNA分析呈4232排列特征,在五个 (S_1、s_2和L_2—L_4) 变异型中.长 (L) 型为主,L_3型占优势。EM鉴定HRV颗粒直径为75—80nm,双层结构,空心和实心两种。研究结果证实HRV是西藏地区腹泻的主要病毒病原,肠遭腺病毒次之,对制订防治对策提供了科学依据。From May 1990 to April 1992, studies on viral etiology of infectious diarrhea were made according to the methods stipulated by WHO in Tibet for the first time and 1557 fecal samples were collected from patients with diarrhea. The specimens were examine by ELISA, SDS-PAGE and EM and viruses were found in 487 cases, with a positive rate of 31.28％. Among the positive cases, 26.33％ were caused by HRV, 3.08％ by Ede, 1.09％ by Roev and 0.77％ by Stv. Genome analysis showed that most of the HRV had larger RNA segments and morphology examination found that HRV particles had diameters of 75-80mm, some having cores and some having not. It was found that the outbreaks occurred in summer (25％) and in spring and winter (35％), 44.18％ of the patients were months old and 39.22％ three years old.

关 键 词：腹泻病 病毒病原 HRV流行病学 

分 类 号：R82[医药卫生—临床医学]