建立新生儿缺氧缺血性脑病动物模型  

AN ANIMAL MODEL FOR NEWBORN HYPOXIA-ISCHEMIC ENCEPALOPATHY

作　　者：吴婉芳[1] 徐放生[1] 张莉莉[2] 蔡玲玲[2] 林久治[2] 

机构地区：[1]首都儿科研究所新生儿科 [2]首都儿科研究所病理研究室

出　　处：《中国新生儿科杂志》1992年第6期265-267,288,共4页Chinese Journal of Neonatology

摘　　要：结扎68只7日龄新生大鼠左侧颈总动脉,然后吸入8％浓度氧2小时,死亡8只。存活的60只新生大鼠体重增长缓慢,52/60只有夹尾左旋;缺氧后44～48小时处死,大体检查可见显示一侧脑变大,颜色变白或转化;显微镜下检查见33/35只的脑组织有不同程度的神经细胞坏死;缺氧缺血组的结扎侧脑半球含水量显著增高。实验结果表明此模型可以较好地用于新生儿缺氧缺血体脑病的进一步研究。Sixty eight 7-day old wistar rats were operated by ligating their left common carotid artery and exposing them to 8% oxygen for two hours. Sixty surviving animals were observed. Results showed that the treat- ed rats grew much slower than the control animals. 52/60 rats developed signs of circling to left after their tails were pinched. All rats were killed after hypoxia 44-48 hours. Macroscopically, 34/60 brains showed swelling, turning white in color, and softening. Under microseopynecrosis of the neural cells were found in 32/35 cases. Water content significan- tly increased at the ipsilatereal hemispheres in hypoxia- ischem is group. It showed that this model were good for research of newborn hypoxia-isc- hemic encephalopathy.

关 键 词：新生大鼠 缺氧缺血性脑病 动物模型 

分 类 号：R72[医药卫生—儿科]