高原低氧环境对大鼠红细胞和组织中SOD活性的影响及中药调节效应的观察  

THE EFFECTS OF HYPOXIA ON SOD IN ERYTHROcYTE AND TISSUSES OF RATS AT HIGH ALTITUDE:cHINESE DRUGS ADJUSTEMENT

作　　者：王芝山[1] 张永洁[1] 王平[1] 曹延柏[1] 姜平[1] 

机构地区：[1]青海省中医院

出　　处：《高原医学杂志》1992年第1期25-27,共3页Journal of High Altitude Medicine

摘　　要：平原地区大鼠进入高原地区后,其红细胞中sOD活性显著降低(P<0.05,P<0.01);经服红景天素后红细胞SOD活性增高与NS组比较P<0.05,P<0.01。高原地区大鼠以肝、脑、肾组织中SOD活性降低最为明显,其中阿尼玛卿山组与西安组比较P<0.01或P<0.001;西宁组与西安组比较P<0.05或P<0.01。红景天素组大鼠进入海拔5100m地区后,其脑和肾组织中SOD活性较NS组显著升高(P<0.01或P<0.001)。提示红景天素能有效地防治大鼠急进高原后所引起的红细胞和组织中SOD活性的降低,且随着海拔的升高,此种效应更为明显。The SOD activity of red blood cell of the rats decreased singinficat(p<0.05,p<0.01),when they were exposured to high altitude from sea level,and it was highly increased compared with NS group(p< 0.05,p<0.01),The SOD activity of rats in high altitude group much lowered in the tissuse of the liver, brain and kidney,of which,it is p<0.01 or p<0.001,in Anymaqen group as compared with Xian group, but p<0.05 or p<0.01,as Xining with xian.The SOD activity of brain and kidney in rats being ascended to altitude of 5 100m was more important in the group with Rhedosin than in NS group.The results suggest that the prophylaxis and treatment of what the SOD activity in erythrocyte and tissuse of rats acutive exposuring to high altitude decrensed credit to the Rhodosin,and these effects are more remarkable with a arising altitude.

关 键 词：高原低氧 超氧化物歧化酶 红景天素 

分 类 号：R8[医药卫生—临床医学]