阿尼玛卿山地区高原鼠兔大脑5——羟色胺含量的初步探讨  

A PRELIMINARY EXPLORATION FOR 5—HT CONTENTS OF CEREBRUM PLATEAU PIKA AT MT.ANIMAQING

作　　者：陈华伟[1] 王志刚[1] 苏明华[1] 

机构地区：[1]青海省高原医学科学研究所生化室

出　　处：《高原医学杂志》1992年第1期28-29,共2页Journal of High Altitude Medicine

摘　　要：本文采用荧光技术对生活在海拔4500m、3600m高原鼠兔和生活在北京的Wister大鼠脑组织中5——羟色胺含量作了测定。结果表明二个海拔相差900m的鼠兔脑5—羟色胺含量无显著性差异,两者与Wistar大鼠脑5—羟色胺含量比较也无显著性差异(P>0.05)结果提示:慢性低氧对高原鼠兔脑5—羟色胺的代谢无影响。也许是经过世代生息自然选择的结果。因此,鼠兔在低氧环境中脑5—羟色胺代谢保持了自身限速步骤。保持了内环境的相对稳定。这也许是鼠兔适应机制之一。With fluorescence technique,we measured the cerebral 5—HTcontents in plateau pikas lived in 4500m and 3600m altitude and Wistar rats lived in Beijing(sea level).From our experiment,the 5—HT contents of cerebrum were same in pikas lived in two different altitude and there were no significant differences between the two of them(p>0.05). The results indicated that the chrKSonic hypoxia did not influence the 5—HT metabolism for pika, therefore,the contents of 5—hydroxylase has rate—limiting effect in synthesis and decomposition of cerebral 5—HT、For this reason,the relative stability in the internal environment of organism which can be an adaptative mechanism of altitude pika.

关 键 词：高原鼠兔 5—羟色胺 低氧 脑干 

分 类 号：R8[医药卫生—临床医学]