阿尼玛卿山高原鼠兔心肌、骨骼肌、肝、肾SDH与LDH组织化学的观察  

A HISTOCHEMICAL OBSERVATION ON SDH AND LDH OF CARDIAC AND SKELETAL MUSCLE,LIVER AND KIDNEY IN ANIMAQING ALTITUDE PIKA

作　　者：苏明华[1] 王志刚[1] 温佳林 陈华伟[1] 火克信 寇星灿 

机构地区：[1]青海省高原医学科学研究所 [2]中国医学科学院卫生学校

出　　处：《高原医学杂志》1992年第4期46-48,共3页Journal of High Altitude Medicine

摘　　要：本文报道了生活在阿尼玛卿山(海拔4500m)的高原鼠兔与在平原(北京)的wistar大鼠心肌,骨骼肌(腓肠肌),肝及肾组织内琥珀酸脱氢酶(SDH)与乳酸脱氢酶(LDH)的活性测定,高原鼠兔心肌,骨骼肌中的SDH活性明显高于wistar大鼠,LDH活性无明显改变;wistar大鼠的肝小叶外带处SDH和LDH活性很强,而高原鼠兔的酶反应沉淀物均匀地分布在整个肝小叶中。我们认为心肌和骨骼肌中SDH活性增强,是高原鼠兔对高原低氧适应的一种机体代偿反应,SDH可作为高原低氧适应动物的一个标志酶。This article reports an activity assay for SDH and LDH of cardiac and skeletal muscle(gastrocnemius muscle),liver and kidney tissues in Animaqing altitude pika and Wistar rat lived in 4 500M and plain(Bei jing)separately. The SDH activities of cardiac and skeletal muscles in pika were higher than that in rat, but LDH activities were not changed obviously, we had also found that the SDH and LDH activities of Wistar rat were clearly appeared on the external zone of hepatic lobules,ho weve er,the sediments of enzyme reaction of pika were distributed evenly over whole hepatic lobules. Authous regard the increasing SDH activity in cardiac and skeletal muscles is a compensatory mechanism of pika which had adapted the hypoxic altitude, therefore, the SDH may become a markerenzyme for adapted animal at high altitude.

关 键 词：高原鼠兔 SDH 低氧适应 标志酶 

分 类 号：R8[医药卫生—临床医学]